McClatchy News Service
David Anderson reads on his Kindle while undergoing dialysis on April 10 at the UCSF Dialysis Center at Mount Zion hospital in San Francisco. Anderson does the three hour routine three times a week.
SAN FRANCISCO — No matter what else is happening in his life, David Anderson knows he cannot go far from the dialysis machine that sustains him.
Jobs, vacations, get-togethers with friends — everything takes a back seat to his thrice-weekly treatments that do the work of his failing kidneys.
But across town, University of California-San Francisco researchers are using Silicon Valley technology to create a device they hope can untether the 63-year-old San Franciscan and 380,000 other Americans who rely on dialysis to cope with kidney disease.
They’re developing an implantable, artificial kidney that would shrink the refrigerator-size dialysis machine into a device the size of a coffee cup and perform functions a dialysis machine cannot do.
Anderson, who has been on dialysis more than five years. said he would gladly be the first test case. “I wouldn’t hesitate for a second,” he said. “It’s just amazing. You want to live long enough to see some of this in place.”
The device has shown such promise that the U.S. Food and Drug Administration last year selected it as one of three projects for a special fast-track approval process. Researchers hope it will be ready for human trials in 2017.
“We realized we could achieve a dialysis filter that would be one-twentieth the size of what’s commercially available, and would require so little power that we could drive it just off blood pressure alone,” said Shuvo Roy, a UCSF associate professor of bioengineering and therapeutic sciences. Researchers are using silicon nanotechnology to design the special filter.
Roy is leading a team of 40 scientists working on the project at nine institutions around the country.
He believes the device has the potential to save the federal Medicare program millions of dollars.
A room-size, external model of the technique was shown to work for very sick patients at the University of Michigan.
More than 600,000 Americans, and nearly 2 million people worldwide, have end-stage renal disease, the complete or nearly complete failure of kidneys.
For decades, little has changed in the treatments available, even though the number of patients is rising by 5 percent a year, mainly because of growing rates of diabetes and high blood pressure.
The best option for those with failing kidneys is a kidney transplant. But not nearly enough organs are available. With more than 95,000 people on a waiting list, and about 18,000 kidney transplants each year, most people are left out.
In 2011, nearly 5,000 people died while awaiting kidney transplants.
That leaves dialysis to help keep people alive until a transplant becomes available. But it is a less-than-ideal solution. —-MCT